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Xinqiao Jia   faculty web page

Salivary Gland Tissue Engineering

Radiation therapy for head and neck cancer results in atrophy, fibrosis, and degeneration of salivary gland tissue, leading to salivary gland hypofunction and xerostomia. This condition affects approximately 40,000 new patients annually in the US. Xerostomia after radiation therapy results in inability to comfortably swallow, taste or articulate. Salivary immune dysfunction after radiation results in dental decay and oral cavity infections. The quality of life in cancer survivors is markedly diminished. Currently, there is no preventive or curative therapy for xerostomia. We are developing tissue engineering strategies for functional salivary gland regeneration.

COLLABORATORS

Professor Cindy Farach-Carson, Department of Biological Sciences, University of Delaware

Dr. Robert Witt, Helen F. Graham Cancer Center, Christiana Care Hospital

Project Staff

Grad Students
Alexandra Farran
Amit Kumar Jha
Sarah Grieshaber

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